Effect of Some Plant Growth Hormones on the Performance of Artemisia vulgaris L. Cuttings

In the wake of the novel coronavirus (COVID-19), many plant material such as artemisia (Artemisia vulgaris L) have received renewed attention as cheap, easy-to-make treatment for many infections. However, the proliferation of artemisia from seeds is often a lengthy process. Here we investigated the role of commercial (Indol-3-butyric acid - IBA, Natural Rooting Hormone Powder - NRHP, Apple Cider Vinegar - ACV) and cottage-made (coconut water - CW and aloe vera gel - AVG) rooting hormone, and water as control (CONT) on the proliferation of artemisia cuttings in a greenhouse experiment in 2021. The survival of artemisia cuttings did not differ significantly (P > .05) across the treatments. The highest number of stems (19) and plant height (138.0 cm) was observed from CW + AVG, and the differed significantly from the others (P < .05) from the others. AVG produced the highest number of leaves per plant (1466), followed by CW (1317), CW + AVG (1278), and IBA (1241). The leaf dry weight was highest in CW + AVG, followed by those of CW and IBA. A similar pettern was observed for the root dry weight. The findings from this study showed that cottage-made plant based (coconut water and aloe vera gel) growth hormone has comparable effect to commercially available IBA on overall performance of artemisia cuttings. This study has great implications for low-tech proliferation of artemisia.

Phytotherapy in the virus infections

The study is a review of natural raw materials that can prevent infection and help treat viral infections, including those that cause COVID-19. The condition of not getting infected with pathogens that cause infections of the upper and lower respiratory tract is high the body resistance. An important element that influences the proper immunity of the body is the diet. The functioning of the immune system is improved by bee products, and plant materials: purple coneflower herb, flower and root, licorice root, aloe gel and Baikal skullcap root, as well as black cumin seed oil, chaga mushroom, lemon balm leaves and chamomile flowers. Strengthening immunity is conducive to maintaining a good mood and reducing stress. The antiviral activity has been confirmed for many plant materials, especially those containing essential oils. Natural products can be used for prevention and treatment. The country that copes best with the coronavirus epidemic is China, thanks to a combination of academic and natural medicine. The study quotes an excerpt from the "Handbook of COVID-19 Prevention and Treatment", prepared by Chinese doctors, with particular attention to the recipes used by them.

Employing an in-silico approach in the evaluation of Aloe vera metabolites as inhibitors of Omicron RBD and the ROS-dependent cellular signaling processes

The pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is related to increased reactive oxygen species (ROS) formation. This increasing ROS formation can mediate ROS-dependent cellular signaling processes inducing cytokines and inflammations that worsen the disease. The severity of coronavirus disease 2019 (COVID-19) can progress due to the self-sustaining cycle of ROS release, inflammatory mediators, and cellular damage. For the treatment, Aloe vera is a promising plant that has the potential to be used. In this study, therefore, we identified the metabolite composition of A. vera peel and gel using liquid chromatography-mass spectrometry (LC-MS). The metabolites were molecularly docked to Omicron receptor-binding domain (RBD) and ROS-producing enzymes to obtain medicinal compounds to inhibit these targets. The LC-MS analysis revealed the peel and gel compositions are distinct, in which 13 metabolites are identified in the peel and 12 in the gel. Furthermore, these metabolites might be promising inhibitors against Omicron variant SARS-CoV-2 RBD and ROS-producing enzymes based on the docking scores and the number of bonds formed. Thus, A. vera is one promising candidate for COVID-19 treatment due to its potential to alter the RBD function of forming a complex with ACE2 and inhibit the ROS-dependent cellular signaling processes related to COVID-19 pathogenesis and disease severity progression © 2023 Billy Johnson Kepel et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/)

In situ electrospun aloe-nanofiber membrane for chronic wound healing.

Alleviating excessive inflammation while accelerating chronic wound healing to prevent wound infection has remained challenging, especially during the coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 when patients experienced difficulties with receive appropriate healthcare. We addressed this issue by developing handheld electrospun aloe-nanofiber membranes (ANFMs) with convenient, environmentally friendly properties and a therapeutic capacity for wound closure. Our results showed that ANFMs fabricated with high molecular weight polyvinyl alcohol (PVA) to form fibers during electrospinning had uniform fibrous architecture and a porous structure. Given the value of aloe gel in accelerating wound healing, liquid extracts from ANFMs significantly downregulated the expression of the pro-inflammatory genes, interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS), and markedly suppress the generation of reactive oxygen species (ROS) induced by lipopolysaccharide in RAW264.7 macrophages. These results indicated the excellent antioxidant and anti-inflammatory effects of ANFMs. After implantation into a mouse diabetic wound model for 12 days in situ, ANFMs notably expedited chronic wound healing via promoting angiogenesis and enhancing cell viability. Our ANFMs generated by handheld electrospinning in situ healed chronic wounds offer a convenient and promising alternative for patients to heal their own wounds under variable conditions.

Analytical review of Tiryaq-i-Wabai - A Unani panacea for the control of COVID-19.

Introduction: COVID-19 has affected the whole world drastically and led to a substantial loss of human life. Relentless research is underway to identify effective treatment to control the disease. Traditional systems are also being explored to search for a potent drug. Unani formulation 'Tiryaq-i-Wabai' has long been used in cholera, plague and other epidemic diseases. This review is aimed at analysing the possible role of Tiryaq-i-Wabai in the prevention and control of COVID-19. Methodology: Unani classical texts and Pharmacopoeias available in the library of Regional Research Institute of Unani Medicine, Chennai were reviewed to collect information related to epidemics, commonly prescribed drugs during epidemics, and therapeutic uses of Tiryaq-i-Wabai ingredients. ScienceDirect, Springer, PubMed and Google Scholar were searched to collect information regarding current pandemic and pharmacological activities of ingredients and phytoconstituents present in the formulation. The collected data was analyzed and interpreted. Results: Tiryaq-i-Wabai was found to be the most recommended prophylactic and curative drug during epidemics. The formulation ingredients, Sibr (Aloe vera (L.) Burm.f.), Murr Makki (Commiphora myrrha (T.Nees) Engl.) and Zafran (Crocus sativus L.) are categorized under Tiryaqi Advia (literally - antidote drugs) and are considered to be very effective in SARS related conditions. These ingredients have been reported to exhibit immunomodulatory, antioxidant, antiviral, antibacterial, antitussive, smooth muscle relaxant, antipyretic and anti-inflammatory activities corroborating the traditional use of Tiryaq-i-Wabai. Conclusion: Scientific data imply great potential and utility of the formulation which could be a possible alternative approach for the prevention and control of current and future pandemics.

Immunomodulatory meaning of diet and COVID-19

Introduction and objective:The latest scientific reports showed that there is a relationship between the state of the gastrointestinal tract and the immune system, and the incidence of COVID-19. Diet can exert an immunomodulatory effect and regulate the immune response of an organism. The aim of the review is to show the effects of immunomodulators contained/supplemented in a diet on the infection SARS-CoV-2 and the course of COVID-19. Review methods:The literature review was conducted using PubMed, Google Scholar and the Medline database. Abbreviated description of the state of knowledge:Regular vitamin D supplementation significantly reduces the risk of respiratory infection with SARS-CoV-2;vitamin C may inhibit the expression of the ACE2 receptor in human small alveolar epithelial cells and limit the penetration of SARS-CoV-2;reduced iron levels predispose people to severe COVID-19 symptoms;selenium deficiency may be responsible for a decreased level of antibodies and NK cell cytotoxicity. Alo.. vera isolated polysaccharides strengthens the immune system;the quercetin and ellagic acid in combination with virus proteins show potential antiviral activity against SARSCoV- 2. Subsequently, adaptogens, ginger, echinacea and curcumin - showed anti-inflammatory effects. Also, the optimal composition of the gut microbiota improved/maintained the integrity of the lymphoid tissue found in the gastrointestinal tract (GALT) and the functioning of the gut-pulmonary axis. Summary:Natural immunomodulators may be a relatively safe therapeutic option in patients during the course of COVID-19, but there are still no official recommendations for their practical use in therapy. It should be emphasized that there is a need for further scientific research into the mechanisms of action and efficacy of phytotherapy in the context of the effectiveness of plant-based immunostimulants in alleviating the course of COVID-19 disease.

In silico-based studies on phytochemicals from native Indian plants as potential inhibitors of SARS-CoV-2

This study aims to analyze the AntiCovid effect of Phytocompounds extracted from Native Indian Plant species by computational methods such as Molecular Docking. Through this study keeping the Indian Heritage alive we characterized the ability of these phytochemicals as inhibiting agents of the Main Protease enzyme of this Virus. The lack of any effective treatment and the reoccurrence of cases despite Vaccination necessitates the quick provision of anti-SARS-CoV-2 drugs. Natural substances are getting a lot of attention for SARS-CoV-2 therapy as they have proven antimicrobial activities and are a key source for numerous antiviral drugs. Despite the fact that this virus has several identified target receptors, Main Protease (Mpro) is crucial for viral replication. In this study, 26 phytochemicals from 10 native Indian plant species were studied. Our docking studies demonstrated that compounds Quercetin, Withaferin A, Sominone, and Nimbin were likely to be more favorable than the natural inhibitor N3, with binding energies of-8.42, -9.21, -9.95, and -8.88 kcal/mol, respectively. These four candidate natural compounds were further examined for their bioavailability scores through ADMET analysis to prove the safety of these compounds as well as their drug likeliness. Through the results it was indicated that these natural phytochemicals have a significant potential of inhibiting the SARS-CoV-2 Mpro enzyme and might be utilized to treat SARS-CoV-2 and manage public health, subject to in vitro validation in the future.

The effect of antioxidant aloe vera as a screen protector to decrease light intensity

The emergence of the Covid-19 pandemic had a major impact on education, resulting in an increase in the use of laptops. In order to minimize the acceleration of macular degeneration, it is necessary to develop technology to protect the surface of the screen, namely using the antioxidant aloe vera. It contains lutein and zeaxanthin. Aloe vera have anti-inflammatory effects and are found in the lens of the human eye. The purpose of this study was to prevent the occurrence of macular degeneration. The simple method used was conducted by aloe vera sonication following by mixing the aloe vera using TPU (thermoplastic polyurethane). All experiment was carried out through factorial design with two variables, i.e weight ratio of TPU and aloe vera and curing temperature. This research was statistically carried out by varying the weight ratio thermoplastic polyurethane/aloe vera (1-4) and temperature (30-40oC). The result showed the model was released significant in ANOVA assesment. Furthermore, testing the luxmeter as many as 13 screen protector variables then processed with a design expert application, obtained F-value data of 6.83 and P-value of 0.0127 (less than 0.0500). © 2023 Author(s).

Herbal and Ayurvedic Plants as Remedial Approach for Viral Diseases with Focus on COVID-19: A Narrative Review

Background: Infectious diseases have posed a major threat to human survival for centu-ries and can devastate entire populations. Recently, the global outbreak of COVID-19 has increased exponentially, affecting more than 200 countries and millions of lives since the fall of 2019, largely due to the ineffectiveness of existing antiviral therapies. WHO announced it a public health emer-gency of international concern. A significant waiting period in antiviral therapy hindered by the rapid evolution of severe acute respiratory syndrome-coronavirus-2 aggravated the situation ensuing imposition of strict laws (e.g., communal dissociation, international travel restrictions, and mainte-nance of hygiene) that would help in inhibiting further outspread of COVID-19. Ayurveda system of medicine offers a holistic approach to the COVID-19 pandemic. Objective(s): This review aims to highlight the potential of medicinal herbs and Ayurvedic drugs as the remedial approach for viral diseases, such as COVID-19. Method(s): We reviewed the literature from journal publication websites and electronic databases, such as Bentham, Science Direct, Pub Med, Scopus, USFDA, etc. Result(s): The drugs used in the traditional system of medicine have the potential to prevent and cure the infected patient. Ayurvedic therapies are known for regulating immunity and rejuvenation properties that behold much promise in the management of COVID-19 disease. Government of India, Ministry of AYUSH recommends some precautionary fitness measures and an increase in immunity with special reference to respiratory health. Conclusion(s): While there is no medication for COVID-19 as of now, taking preventive measures and boosting body immunity is highly recommended. A number of medicinal plants that play an im-portant role in revitalizing the immune system are easily accessible in home remedies.Copyright © 2023 Bentham Science Publishers.

Barbaloin: an amazing chemical from the 'wonder plant' with multidimensional pharmacological attributes.

Aloe vera (L.) Burm.f. is nicknamed the 'Miracle plant' or sometimes as the 'Wonder plant'. It is a plant that has been used since ancient times for the innumerable health benefits associated with it. It is one of the important plants that has its use in conventional medicinal treatments. It is a perennial succulent, drought-tolerant member of the family Asphodelaceae. There are scores of properties associated with the plant that help in curing various forms of human ailments. Extracts and gels obtained from plants have been shown to be wonderful healers of different conditions, mainly various skin problems. Also, this plant is popular in the cosmetics industry. The underlying properties of the plant are now mainly associated with the natural phytochemicals present in the plant. Diverse groups of phytoingredients are found in the plant, including various phenolics, amino acids, sugars, vitamins, and different other organic compounds, too. One of the primary ingredients found in the plant is the aloin molecule. It is an anthraquinone derivative and exists as an isomer of Aloin A and Aloin B. Barbaloin belonging to the first group is a glucoside of the aloe-emodin anthrone molecule. Various types of pharmacological properties exhibited by the plant can be attributed to this chemical. Few significant ones are antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, anti-microbial, and anti-viral, along with their different immunity-boosting actions. Recently, molecular coupling studies have also found the role of these molecules as a potential cure against the ongoing COVID-19 disease. This study comprehensively focuses on the numerous pharmacological actions of the primary compound barbaloin obtained from the Aloe vera plant along with the mechanism of action and the potent application of these natural molecules under various conditions.

Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo, soap, and sunscreen. However, the demand for these gel-based products has led to a surplus production of Aloe vera processing waste. An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month. Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer. A sustainable management system for the Aloe vera processing waste should be considered, due to the negative societal and environmental impacts of the currents waste disposal methods. Therefore, this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products, such as animal and aquaculture feeds, biosorbents, biofuel and natural polymers. Researchers have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various pollutants. Several studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol, mixed alcohol fuels, biogas and syn-gas. Aloe vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing, tissue engineering and drug delivery systems. Aloe vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin, aloin and aloeresin. These value-added bioactive compounds have various applications in the cosmetics (non-steroidal anti-inflammatory, tyrosinase inhibitors) and pharmaceutical (anticancer agent and COVID 19 inhibitors) industry. © 2023, Tech Science Press. All rights reserved.

The phytotherapeutic potential of commercial South African medicinal plants: current knowledge and future prospects

South Africa, a country considered affluent in nature, ranks third in global biodiversity and encompasses approximately 9% of higher plants on planet Earth. Many indigenous plants have been utilised as herbal medicine, proving successful in treating numerous ailments. From the common cold to pandemic maladies such as COVID-19 in the 21st century and the treatment of incurable diseases, South African inhabitants have found great promise in the healing properties of these plants. Phytomedicine is a rapidly evolving topic, with in-depth bioactive composition analysis, identifying therapeutic action mechanisms, and disease prevention. While we are now poised to take advantage of nature's medicine cabinet with greater scientific vigour, it remains critical that these practises are done with caution. Overharvesting significantly impacts biodiversity and cultivation practices amidst the beautiful nature of these nutraceuticals. This book chapter focuses on the therapeutic potential of commonly used South African medicinal plants, their ethnopharmacological properties, and how we can conserve this treasure cove we call home for future generations.

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.

The cytokine storm is highly associated with inflammatory-type disease severity and patients' survival. Plant polysaccharides, the main natural phytomedicine source, have a great potential to be an effective drug to treat cytokine storm. Herein we found that a polymeric acemannan (ABPA1) isolated from Aloe Vera Barbadensis extract C (AVBEC) exerted prominent inhibitory effects on inflammation-induced cytokine storm. The results displayed that ABPA1 effectively suppressed LPS-induced proinflammatory cytokines release in vitro. Moreover, ABPA1 treatment alleviated the cytokine storm and tissue damage in LPS- and IAV-induced mouse pneumonia models, and altered the phenotypic balance of macrophages in lung tissues. Functionally, ABPA1 enhanced macrophage M2 polarization and phagocytosis in RAW264.7 cells and inhibited LPS-induced M1 polarization. Mechanistically, ABPA1 enhanced mitochondrial metabolism and OXPHOS through activated PI3K/Akt/GSK-3ß signalling pathway. Overall, our findings suggest that ABPA1 may modulate macrophage activation and mitochondrial metabolism by targeting PI3K/Akt/GSK-3ß signalling pathway, thereby alleviating cytokine storm and inflammation.

Preparation of soap using a steam extraction process from leaves of Azadirachta indica, Ocimum basilicum, Hibiscus-rosa-sinensis Flowers, Acalypha indica, and Aloe barbadensis Leaflets

Soaps are used widely by humans in many aspects. Exclusively, the emergence of the SARS-Cov-2 virus made people wash their hands frequently to disinfect the virus to prevent virus infection. Soaps made of herbals possess constituents that goodness the skin as well to rejuvenate the mind and body factors. Dried leaves of Basil, Neem and Acalypha Indica, Aloe vera, and Hibiscus flower are used here to prepare homemade soap. The steam distillation process is an imperative process by which the oils are used from raw materials like dried leaves for the preparation of soaps. Extracts obtained from the herbal plants are used as additives in the preparation of soap that would be added besides the lye and other constituents. Lye preferred here is Sodium Hydroxide (NaOH) and the cast shapes utilized here in determining the soap shape are Elliptic and Rectangle. pH value, the total fatty matter is determined using respective methodologies, and the materials used in the preparation of soap are estimated using the accessible software called SoapCalc Recipe Calculator. Soaps made using the mentioned ingredients are safe and robust for cleaning the skin and hands.

Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo, soap, and sunscreen. However, the demand for these gel-based products has led to a surplus production of Aloe vera processing waste. An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month. Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer. A sustainable management system for the Aloe vera processing waste should be considered, due to the negative societal and environmental impacts of the currents waste disposal methods. Therefore, this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products, such as animal and aquaculture feeds, biosorbents, biofuel and natural polymers. Researchers have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various pollutants. Several studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol, mixed alcohol fuels, biogas and syngas. Aloe vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing, tissue engineering and drug delivery systems. Aloe vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin, aloin and aloeresin. These value-added bioactive compounds have various applications in the cosmetics (non-steroidal anti-inflammatory, tyrosinase inhibitors) and pharmaceutical (anticancer agent and COVID 19 inhibitors) industry.

Las plantas medicinales en la prevención y el tratamiento de la COVID-19

Introduction: medicinal plants are a useful and accessible therapeutic resource to solve health problems. COVID-19 has been the most difficult health challenge that man has faced in the XXI century and to combat it he has resorted to all possible therapeutic options, including medicinal plants. Objective: to describe the use of medicinal plants against COVID-19 in the Municipality of Santa Clara. Methods: an exploratory descriptive study was carried out in Santa Clara, Villa Clara Province, during the months of January and February 2021. Random surveys were applied to people from three popular councils and the use of medicinal plants for this disease was investigated. The different treatment protocols proposed by the Ministry of Public Health and other scientific literature on the subject were reviewed in order to contrast the results obtained. Results: 60 people were surveyed, with a predominance of women and medium level of schooling. 55% referred to the use of the drug. Fifty-five percent reported the use of homemade or pharmaceutical phytopreparations for possible symptoms or as a preventive measure. The most commonly used plants were Aloe barbadensis (aloe vera), Plectranthus amboinicus (French oregano), Citrus aurantium (orange) and Allium cepa (onion). This coincides with that established in the treatment protocols proposed in Cuba from version 1.2. The review of scientific literature showed the proposal of the mentioned plants and others with the purpose of treating symptoms and raising people's immunity (or both). Conclusions: the population of Santa Clara employs medicinal plants and their preparations to prevent and treat symptoms suggestive of COVID-19 in correspondence with what has been established in Cuban treatment protocols. Bibliographic reviews corroborate these medicinal uses. (English) [ FROM AUTHOR] Introducción: las plantas medicinales son un recurso terapéutico útil y accesible para resolver problemas de salud. La COVID-19 ha sido el reto de salud más difícil que el hombre ha enfrentado en el siglo XXI y para combatirla ha acudido a todas las opciones terapéuticas posibles, incluidas las plantas medicinales. Objetivo: describir el uso de plantas medicinales ante la COVID-19 en el Municipio de Santa Clara. Métodos: se realizó un estudio descriptivo exploratorio en Santa Clara, Provincia de Villa Clara, durante los meses de enero y febrero de 2021. Se aplicaron encuestas aleatorias a personas de tres consejos populares y se indagó sobre el uso de plantas medicinales ante esta enfermedad. Fueron revisados los diversos protocolos de tratamiento propuestos por el Ministerio de Salud Pública y otras literaturas científicas que abordan el tema con el objetivo de contrastar los resultados obtenidos. Resultados: se encuestaron 60 personas, predominaron las mujeres y el nivel medio de escolaridad. El 55% refirió el uso de fitopreparados caseros o farmacéuticos ante posibles síntomas o de manera preventiva. Las plantas más empleadas fueron Aloe barbadensis (sábila), Plectranthus amboinicus (orégano francés), Citrus aurantium (naranja) y Allium cepa (cebolla). Esto coincide con lo establecido en los protocolos de tratamiento propuestos en Cuba a partir de la versión 1.2. La revisión de literatura científica mostró la propuesta de las plantas mencionadas y otras más con el propósito de tratar síntomas y de elevar la inmunidad de las personas (o ambos). Conclusiones: la población de Santa Clara emplea plantas medicinales y sus preparados para prevenir y tratar síntomas sugestivos de COVID-19 en correspondencia con lo establecido en los protocolos de tratamiento cubanos. Revisiones bibliográficas realizadas corroboran estos usos medicinales. (Spanish) [ FROM AUTHOR] Copyright of Acta Médica del Centro is the property of Hospital Provincial Universitario Clinico Quirurgico Arnaldo Milian Castro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Role of the Unani System of Medicine in Countering Epidemic Diseases, Considering Coronavirus Pandemic -19

Since December 2019 world faces a respiratory pandemic named Coronavirus disease-19 (COVID-19). COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The term epidemic was coined by Hippocrates who is considered the father of Unani medicine which is based on four humours. In the Unani System of Medicine (USM) equivalent term for the epidemic is Wabā'. In classical Unani literature symptoms of Nazla-i-Wabā'iyya and Humma-i-Wabā'iyya closely resemble the symptoms of COVID-19. Major manifestations of this outbreak are cough, fever, headache, nausea, and breathlessness. This pandemic takes place due to a change in the quality of the surrounding air. We searched different databases electronically using the terms “COVID-19 or Coronavirus”, “Wabā or infectious disease”, “Unani immunomodulators”, ''Herbal immunomodulators'', ''Anti-viral herbal drugs'', Herbal fumigation and “Nazla-i-Wabā'iyya or Nazla Wabā'ī”. We also gone through different classical textbooks of USM available in the NRIUMSD library. We reviewed the concept of Wabā', its prevention, and management strategies available in USM. We also searched antiviral, immunomodulation, fumigation activities of Unani drugs. Unani physicians advocated general measures of physical distancing, health hygiene, isolation, quarantine, and immunomodulation. As a preventive measure, various immunomodulatory drugs like Asgandh, Aam, Babuna, Gilo, Satawar, and Kalonji and antidotes such as Tiryāq Wabā'i have been described in the literature. The ingredients of Tiryāq-i-Wabā'i include Aloe barbedensis, Crocus sativus, and Commiphora myrrha. Several fumigants like Sandal, Ood, Kafoor, Loban, and Jhau are also mentioned in the management of the epidemic. For symptomatic management various antiviral, antipyretic and antitussive drugs are described well. Many evidence-based studies have already been reported for single drugs and formulations used in the USM.The Khamira Marwareed possesses antiviral, cardiotonic, and immunomodulatory activity. Single drugs such as Khaksi, Asgandh, Adusa, Chiriata, and Zanjabeel possess antipyretic, immunomodulatory, antitussive, antibacterial, and antiviral activities respectively. The knowledge from classical Unani literature and scientific researches may be useful in the prevention and management of COVID-19 like epidemic diseases. This review article aims to find out the concept of the pandemic, prevention, and management strategies existing in the USM.

Ayurvedic antiviral agents: Overview of medicinal plants perspective

In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. On the basis of randomized controlled studies and in-vivo studies, and in-vitro studies, some agents are utilized all across the globe. Progressively numerous studies on therapy of antivirals have been increased. Though, efficacy remains disputable for antiviral drugs that are employed for viral disorders. The viral diseases are challenging for the health of people around the world cause significant increase in mortality and enhance crises. There are many synthetic antiviral drugs that have a large number of side effects and have narrow therapeutic window range, while in the other hand herbal formulations have minimized side effects. The advantages of herbal formulation over synthetic drugs encourage us to devise and expand new herbal moieties against the emerging viral infections. The medicinal plants contain phytochemicals that have antiviral properties. In this paper, the activity of antiviral agents from medicinal plants which have importance in Ayurveda, are discussed along with their source.

Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control.

Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. Antiseptic iodophors and many phytochemicals are unaffected by AMR. Surgical site and wound infections can be prevented or treated by utilizing such compounds on sutures and bandages. Coating surgical face masks with these antimicrobials can reduce microbial infections and attenuate their burden on the environment by re-use. The facile combination of Aloe Vera Barbadensis Miller (AV), Trans-cinnamic acid (TCA) and Iodine (I2) encapsulated in a polyvinylpyrrolidone (PVP) matrix seems a promising alternative to common antimicrobials. The AV-PVP-TCA-I2 formulation was impregnated into sterile discs, medical gauze bandages, surgical sutures and face masks. Morphology, purity and composition were confirmed by several analytical methods. Antimicrobial activity of AV-PVP-TCA-I2 was investigated by disc diffusion methods against ten microbial strains in comparison to gentamycin and nystatin. AV-PVP-TCA-I2 showed excellent antifungal and strong to intermediate antibacterial activities against most of the selected pathogens, especially in bandages and face masks. The title compound has potential use for prevention or treatment of surgical site and wound infections. Coating disposable face masks with AV-PVP-TCA-I2 may be a sustainable solution for their re-use and waste management.

Utilization of Aloe Compounds in Combatting Viral Diseases.

Plants contain underutilized resources of compounds that can be employed to combat viral diseases. Aloe vera (L.) Burm. f. (syn. Aloe barbadensis Mill.) has a long history of use in traditional medicine, and A. vera extracts have been reported to possess a huge breadth of pharmacological activities. Here, we discuss the potential of A. vera compounds as antivirals and immunomodulators for the treatment of viral diseases. In particular, we highlight the use of aloe emodin and acemannan as lead compounds that should be considered for further development in the management and prevention of viral diseases. Given the immunomodulatory capacity of A. vera compounds, especially those found in Aloe gel, we also put forward the idea that these compounds should be considered as adjuvants for viral vaccines. Lastly, we present some of the current limitations to the clinical applications of compounds from Aloe, especially from A. vera.